2025/2026 NSG 533 ADV PHARM: MODULE 1: GI: CHP 17 LATEST UPDATE

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2025/2026 NSG 533 ADV PHARM: MODULE 1: GI: CHP 17 ACTUAL QUESTIONS AND 100% CORRECT ANSWERS Which drug class is most effective in treating erosive lesions:? - Answer -PPIs Name 4 H2RAs: - Answer -Cimetidine (Tagamet) Famotidine (Pepcid) Ranitidine (Zantac) Nizatidine (Axid) What is the action of H2RAs? - Answer -Decrease acid secretion by blocking histamine 2-receptors in gastric parietal cells Name 4 benefits of H2RAs - Answer -1. Relieve GERD symptoms 2. Can be administered prophylactically 3. More effective at controlling chronic GERD symptoms than ANTACIDS 4. Intermittent & routine dosing possible based on degree of symptom control needed. Name 2 drawbacks of H2RAs - Answer -1. Less effective in controlling chronic GERD symptoms than PPIs 2. Renal elimination may require dose adjustment in kidney dysfunction patients What are the side effects associated with H2RAs? - Answer -H/A, nausea (Cimetidine), weak inhibitor, common drug interactions, gynecomastia, & Vit B-12 deficiency which affects patients' Need assistance on Online classes, Exams & Assignments? Reach out for instant help!! Full Course Assistance, Plagiarism-free Essay Writing, Research Paper, Dissertation, Discussion Posts, etc…. Confidential & Secure services. Tutors are available for all subjects! Email now at: tutorjean01@gmail.com tolerance Name the benefits of Antacids - Answer -1. Useful for intermittent treatment of GERD symptoms 2. Immediate symptom relief 3. Usually well-tolerated What are the drawbacks of Antacids? - Answer -1. Requires frequent dosing 2. Aluminum or Magnesium containing antacids may result in electrolyte imbalances esp. in pts. w/renal impairment 3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron products, & thyroid hormones (doses should be several hours apart) What are the side effects of Antacids? - Answer -May cause Constipation or Diarrhea depending on the formulation used What is the Pharmacological Therapy Effectiveness of Antacids? - Answer -Antacids briefly neutralize gastric acid but lacks acidsuppressive properties & are inferior to H2RAs What is the Pharmacological Therapy Effectiveness of H2RAs? - Answer -Histamine-2 Receptor Antagonists decrease acid secretion to a lesser extent than PPIs (& are therefore inferior to PPIs) What is the Pharmacological Therapy Effectiveness of PPIs? - Answer -Proton Pump Inhibitors block the rate-limiting step in acid secretion from gastric parietal cells & block all pathways for gastric acid secretion & therefore are better than H2RAs What is the treatment goal of pharmacological therapy in GERD? - Answer -Increase the pH of gastric content by; 1) Direct gastric acid neutralization 2) Reduce acid production through inhibiting the stimulation of pathways to decrease GERD symptoms and prevent tissue damage Which Bariatric Surgery is effective in reducing GERD symptoms in obese patients? Need assistance on Online classes, Exams & Assignments? Reach out for instant help!! Full Course Assistance, Plagiarism-free Essay Writing, Research Paper, Dissertation, Discussion Posts, etc…. Confidential & Secure services. Tutors are available for all subjects! Email now at: tutorjean01@gmail.com