CPHON EXAM Questions and Verified Answers Latest Update

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CPHON EXAM | Q&A Latest 2025/2026 | 100% PASS Autoimmune Hemolytic Anemia is a group of disorders characterized by - Answer -malfunction of the immune system where antibodies are produced against antigens on the surface of RBSs, resulting in hemolysis T/F RBC survival is proportional to the amount of antibody on the RBC surface; therefore the greater the amount of antibody the more rapidly the RBC is destroyed. - Answer -True Intravascular Hemolysis is - - Answer -RBC lysis in circulation Antibodies bind to the RBC membrane therefore activating the complement cascade - damaged membrane causes increased osmotic pressure within cell and the cell bursts Extravascular hemolysis is - Answer -occurs when complement fixation to RBC fails to activate complement cascade - the complement on the RBC surface interacts with receptors in macrophages in the lungs, liver, and spleen -> RBC phagocytosis Causes of AIHA (4) - Answer -1. Autoimmune disorders (LUPUS) 2. Infections (hepatitis, EBV, myco pneu) 3. Drugs (peni and quinine) 4. Hematologic disorders(Evan's syndrome and paroxysmal nocturnal hemoglobinuria) Incidence of AIHA - Answer -1 case per 80,000 persons Clinical Symptoms of Severe AIHA - - Answer -- pallor - jaundice - fatigue - tachycardia -hypoxia --> organ damage - splenomagaly